Cargando…

RARγ-induced E-cadherin downregulation promotes hepatocellular carcinoma invasion and metastasis

BACKGROUND: Aberrant expression of Retinoic acid receptor γ (RARγ) is implicated in cancer development. Our previous study identified that RARγ functions as a tumor promoter to drive hepatocellular carcinoma (HCC) growth. However, its contribution to HCC invasion and metastasis remains unclear. METH...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gan, Wen-Juan, Wang, Jing-Ru, Zhu, Xiao-Li, He, Xiao-Shun, Guo, Peng-Da, Zhang, Shen, Li, Xiu-Ming, Li, Jian-Ming, Wu, Hua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069892/ https://www.ncbi.nlm.nih.gov/pubmed/27756432 http://dx.doi.org/10.1186/s13046-016-0441-9

Ejemplares similares

Cyclin B1 Suppresses Colorectal Cancer Invasion and Metastasis by Regulating E-Cadherin
por: Fang, Yifeng, et al.
Publicado: (2015)

Reversal by RARα agonist Am580 of c-Myc-induced imbalance in RARα/RARγ expression during MMTV-Myc tumorigenesis
por: Bosch, Almudena, et al.
Publicado: (2012)

The RARγ Oncogene: An Achilles Heel for Some Cancers
por: Brown, Geoffrey, et al.
Publicado: (2021)

Synergistic activation of RARβ and RARγ nuclear receptors restores cell specialization during stem cell differentiation by hijacking RARα-controlled programs
por: Koshy, Aysis, et al.
Publicado: (2022)

LRRC4 Suppresses E-Cadherin-Dependent Collective Cell Invasion and Metastasis in Epithelial Ovarian Cancer
por: Zhao, Chunhua, et al.
Publicado: (2020)

Nur77 deficiency in mice accelerates tumor invasion and metastasis by facilitating TNFα secretion and lowering CSF-1R expression
por: Li, Xiu-Ming, et al.
Publicado: (2017)

Correction: Nur77 deficiency in mice accelerates tumor invasion and metastasis by facilitating TNFα secretion and lowering CSF-1R expression
por: Li, Xiu-Ming, et al.
Publicado: (2017)

RNF2 inhibits E-Cadherin transcription to promote hepatocellular carcinoma metastasis via inducing histone mono-ubiquitination
por: Yao, Lei, et al.
Publicado: (2023)

Understanding the Action of RARγ Agonists on Human Osteochondroma Explants
por: Garcia, Sonia A., et al.
Publicado: (2020)

Antagonizing RARγ Drives Necroptosis of Cancer Stem Cells
por: Brown, Geoffrey
Publicado: (2022)

γ-secretase inhibitors, DAPT and RO4929097, promote the migration of Human Glioma Cells via Smad5-downregulated E-cadherin Expression
por: Chang, Shun-Fu, et al.
Publicado: (2021)

[Corrigendum] Suppression of SIPA‑1 expression may reduce bladder cancer invasion and metastasis via the downregulation of E‑cadherin and ZO‑1
por: Zhang, Ping, et al.
Publicado: (2022)

Positive feedback loop of IL-1β/Akt/RARα/Akt signaling mediates oncogenic property of RARα in gastric carcinoma
por: Ren, Hong-Yue, et al.
Publicado: (2016)

Upregulated expression levels of ADAM10 and EGFR and downregulated expression levels of E-cadherin in hepatocellular carcinomas
por: YUE, YUAN, et al.
Publicado: (2013)

Upregulated expression levels of ADAM10 and EGFR and downregulated expression levels of E-cadherin in hepatocellular carcinomas
Publicado: (2014)

Novel HDAC5-interacting motifs of Tbx3 are essential for the suppression of E-cadherin expression and for the promotion of metastasis in hepatocellular carcinoma
por: Dong, Liang, et al.
Publicado: (2018)

Pygopus-2 promotes invasion and metastasis of hepatic carcinoma cell by decreasing E-cadherin expression
por: Zhang, Sheng, et al.
Publicado: (2015)

MicroRNA-126 inhibits tumor cell invasion and metastasis by downregulating ROCK1 in renal cell carcinoma
por: ZHANG, GUI-MING, et al.
Publicado: (2016)

Effect of Slug-Mediated Down-Regulation of E-Cadherin on Invasiveness and Metastasis of Anaplastic Thyroid Cancer Cells
por: Sheng, Li, et al.
Publicado: (2017)

E-cadherin and α-, β- and γ-catenin expression in prostate cancers: correlation with tumour invasion
por: Morita, N, et al.
Publicado: (1999)

Transcription factor Snai1-1 induces osteosarcoma invasion and metastasis by inhibiting E-cadherin expression
por: YANG, HUIGUANG, et al.
Publicado: (2014)

Differential Downregulation of E-Cadherin and Desmoglein by Epidermal Growth Factor
por: Chavez, Miquella G., et al.
Publicado: (2012)

Bmi-1 promotes the invasion and migration of colon cancer stem cells through the downregulation of E-cadherin
por: Zhang, Zefeng, et al.
Publicado: (2016)

Promoter methylation of P16, RARβ, E-cadherin, cyclin A1 and cytoglobin in oral cancer: quantitative evaluation using pyrosequencing
por: Shaw, R J, et al.
Publicado: (2006)

ARHGAP9 suppresses the migration and invasion of hepatocellular carcinoma cells through up-regulating FOXJ2/E-cadherin
por: Zhang, Hong, et al.
Publicado: (2018)

Retinoic acid and RARγ maintain satellite cell quiescence through regulation of translation initiation
por: Luo, Wenzhe, et al.
Publicado: (2022)

HER2 Upregulates ATF4 to Promote Cell Migration via Activation of ZEB1 and Downregulation of E-Cadherin
por: Zeng, Peng, et al.
Publicado: (2019)

MicroRNA-219-5p Promotes Tumor Growth and Metastasis of Hepatocellular Carcinoma by Regulating Cadherin 1
por: Yang, Jing, et al.
Publicado: (2018)

Deficiency of RARα Suppresses Decidualization via Downregulating CEBPB Transcription in Women With Recurrent Implantation Failure
por: Huang, Caiyi, et al.
Publicado: (2022)

MicroRNA-182 downregulates metastasis suppressor 1 and contributes to metastasis of hepatocellular carcinoma
por: Wang, Jian, et al.
Publicado: (2012)

PHF8 upregulation contributes to autophagic degradation of E-cadherin, epithelial-mesenchymal transition and metastasis in hepatocellular carcinoma
por: Zhou, Wuhua, et al.
Publicado: (2018)

Downregulation of A20 increases the cytotoxicity of IFN-γ in hepatocellular carcinoma cells
por: Yin, Lei, et al.
Publicado: (2017)

Is RARS-T a new disease entity or a subtype of RARS or ET?
por: Bang, Soo-Mee
Publicado: (2010)

Regulation of RXR-RAR Heterodimers by RXR- and RAR-Specific Ligands and Their Combinations
por: le Maire, Albane, et al.
Publicado: (2019)

HNF-4α downregulation promotes tumor migration and invasion by regulating E-cadherin in renal cell carcinoma
por: Gao, Yaohui, et al.
Publicado: (2019)

Lacking hypoxia-mediated downregulation of E-cadherin in cancers of the uterine cervix
por: Mayer, A, et al.
Publicado: (2013)

E-Cadherin Downregulation is Mediated by Promoter Methylation in Canine Prostate Cancer
por: Fonseca-Alves, Carlos Eduardo, et al.
Publicado: (2019)

Downregulation of E-cadherin in pluripotent stem cells triggers partial EMT
por: Aban, C. E., et al.
Publicado: (2021)

Chondroitin sulfate E downregulates N-cadherin and suppresses myotube formation
por: SATOH, Fumi, et al.
Publicado: (2022)

PPAR-γ Ligand Inhibits Nasopharyngeal Carcinoma Cell Proliferation and Metastasis by Regulating E2F2
por: Yang, Ping-Li, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_m67fsc5k66vfng87devm1636lu