Oligomeric interface modulation causes misregulation of purine 5´-nucleotidase in relapsed leukemia

BACKGROUND: Relapsed acute lymphoblastic leukemia (ALL) is one of the main causes of mortality in childhood malignancies. Previous genetic studies demonstrated that chemoresistant ALL is driven by activating mutations in NT5C2, the gene encoding cytosolic 5´-nucleotidase (cN-II). However, molecular...

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Detalles Bibliográficos
Autores principales: Hnízda, Aleš, Škerlová, Jana, Fábry, Milan, Pachl, Petr, Šinalová, Martina, Vrzal, Lukáš, Man, Petr, Novák, Petr, Řezáčová, Pavlína, Veverka, Václav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5070119/
https://www.ncbi.nlm.nih.gov/pubmed/27756303
http://dx.doi.org/10.1186/s12915-016-0313-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5070119/
https://www.ncbi.nlm.nih.gov/pubmed/27756303
http://dx.doi.org/10.1186/s12915-016-0313-y

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