Cargando…

Oligomeric interface modulation causes misregulation of purine 5´-nucleotidase in relapsed leukemia

BACKGROUND: Relapsed acute lymphoblastic leukemia (ALL) is one of the main causes of mortality in childhood malignancies. Previous genetic studies demonstrated that chemoresistant ALL is driven by activating mutations in NT5C2, the gene encoding cytosolic 5´-nucleotidase (cN-II). However, molecular...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hnízda, Aleš, Škerlová, Jana, Fábry, Milan, Pachl, Petr, Šinalová, Martina, Vrzal, Lukáš, Man, Petr, Novák, Petr, Řezáčová, Pavlína, Veverka, Václav
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5070119/ https://www.ncbi.nlm.nih.gov/pubmed/27756303 http://dx.doi.org/10.1186/s12915-016-0313-y

Ejemplares similares

N-Glycosylation can selectively block or foster different receptor–ligand binding modes
por: Vuorio, Joni, et al.
Publicado: (2021)

Kinetic, Thermodynamic, and Structural Analysis of Drug Resistance Mutations in Neuraminidase from the 2009 Pandemic Influenza Virus
por: Pokorná, Jana, et al.
Publicado: (2018)

Design, Synthesis, Biological Evaluation, and Crystallographic Study of Novel Purine Nucleoside Phosphorylase Inhibitors
por: Skácel, Jan, et al.
Publicado: (2023)

DNA-linked inhibitor antibody assay (DIANA) as a new method for screening influenza neuraminidase inhibitors
por: Kožíšek, Milan, et al.
Publicado: (2018)

Multivalency of nucleosome recognition by LEDGF
por: Koutná, Eliška, et al.
Publicado: (2023)

Structural basis of the interaction between the putative adhesion-involved and iron-regulated FrpD and FrpC proteins of Neisseria meningitidis
por: Sviridova, Ekaterina, et al.
Publicado: (2017)

Triggering HIV polyprotein processing by light using rapid photodegradation of a tight-binding protease inhibitor
por: Schimer, Jiří, et al.
Publicado: (2015)

An evolutionary molecular adaptation of an unusual stefin from the liver fluke Fasciola hepatica redefines the cystatin superfamily
por: Buša, Michal, et al.
Publicado: (2023)

Neonicotinoid insecticides limit the potential of spiders to re-colonize disturbed agroecosystems when using silk-mediated dispersal
por: Řezáč, Milan, et al.
Publicado: (2019)

Contact application of neonicotinoids suppresses the predation rate in different densities of prey and induces paralysis of common farmland spiders
por: Řezáč, Milan, et al.
Publicado: (2019)

SAP domain forms a flexible part of DNA aperture in Ku70/80
por: Hnízda, Aleš, et al.
Publicado: (2021)

Azanitrile Inhibitors of the SmCB1 Protease Target Are Lethal to Schistosoma mansoni: Structural and Mechanistic Insights into Chemotype Reactivity
por: Jílková, Adéla, et al.
Publicado: (2020)

NSC348884 cytotoxicity is not mediated by inhibition of nucleophosmin oligomerization
por: Šašinková, Markéta, et al.
Publicado: (2021)

Carborane-Based Carbonic Anhydrase Inhibitors: Insight into CAII/CAIX Specificity from a High-Resolution Crystal Structure, Modeling, and Quantum Chemical Calculations
por: Mader, Pavel, et al.
Publicado: (2014)

Substrate binding modes of purine and pyrimidine nucleotides to human ecto-5′-nucleotidase (CD73) and inhibition by their bisphosphonic acid derivatives
por: Scaletti, Emma, et al.
Publicado: (2021)

Food provisioning to Pardosa spiders decreases the levels of tissue-resident endosymbiotic bacteria
por: Řezáč, Milan, et al.
Publicado: (2023)

X-ray structure of human aldo–keto reductase 1C3 in complex with a bile acid fused tetrazole inhibitor: experimental validation, molecular docking and structural analysis
por: Marinović, Maja A., et al.
Publicado: (2022)

Oligomeric Architecture of Mouse Activating Nkrp1 Receptors on Living Cells
por: Adámková, Ljubina, et al.
Publicado: (2019)

Misregulated Posttranscriptional Checkpoints: Inflammation and Tumorigenesis
por: Brewer, Gary
Publicado: (2001)

Misregulation of the IgH Locus in Thymocytes
por: Kumari, Gita, et al.
Publicado: (2018)

Stereotactic Body Radiotherapy (SBRT) of Pancreatic Cancer—A Critical Review and Practical Consideration
por: Burkoň, Petr, et al.
Publicado: (2022)

Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL
por: Tzoneva, Gannie, et al.
Publicado: (2013)

Transcriptional regulation and its misregulation in Alzheimer’s disease
por: Chen, Xiao-Fen, et al.
Publicado: (2013)

Transcriptional Regulation: Molecules, Involved Mechanisms, and Misregulation
por: Casamassimi, Amelia, et al.
Publicado: (2019)

Misregulation of the expression and activity of DNA methyltransferases in cancer
por: Mensah, Isaiah K, et al.
Publicado: (2021)

Transcriptional Regulation and Its Misregulation in Human Diseases
por: Casamassimi, Amelia, et al.
Publicado: (2023)

Effect of K/Al Molar Ratio on the Thermo-Mechanical Properties of Metakaolinite-Based Geopolymer Composites
por: Kohout, Jan, et al.
Publicado: (2021)

Effect of Different Types of Aluminosilicates on the Thermo-Mechanical Properties of Metakaolinite-Based Geopolymer Composites
por: Kohout, Jan, et al.
Publicado: (2022)

About Pyrimidine 5’-Nucleotidase Deficiency
por: Özsoylu, Şinasi
Publicado: (2013)

Towards personalized chemotherapy of acute lymphoblastic leukemia
por: Hnízda, Aleš, et al.
Publicado: (2018)

Improved Mutual Understanding for Human-Robot Collaboration: Combining Human-Aware Motion Planning with Haptic Feedback Devices for Communicating Planned Trajectory
por: Grushko, Stefan, et al.
Publicado: (2021)

The structural basis for the selectivity of sulfonamido dicarbaboranes toward cancer-associated carbonic anhydrase IX
por: Kugler, Michael, et al.
Publicado: (2020)

Cause or Effect: Misregulation of microRNA Pathways in Neurodegeneration
por: Gascon, Eduardo, et al.
Publicado: (2012)

Small genomic insertions form enhancers that misregulate oncogenes
por: Abraham, Brian J., et al.
Publicado: (2017)

Misregulation of Drosophila Myc Disrupts Circadian Behavior and Metabolism
por: Hsieh, Annie L., et al.
Publicado: (2019)

Transcriptional Regulation of Endogenous Retroviruses and Their Misregulation in Human Diseases
por: Zhang, Qian, et al.
Publicado: (2022)

Ecto-5’-nucleotidase: Structure function relationships
por: Sträter, Norbert
Publicado: (2006)

Intracellular Distribution of 5' Nucleotidase in Rat Liver
por: de Lamirande, Gaston, et al.
Publicado: (1958)

CYTOCHEMICAL LOCALIZATION OF 5'-NUCLEOTIDASE IN SUBCELLULAR FRACTIONS ISOLATED FROM RAT LIVER : I. The Origin of 5'-Nucleotidase Activity in Microsomes
por: Widnell, Christopher C.
Publicado: (1972)

Effect of Aluminosilicates’ Particle Size Distribution on the Microstructural and Mechanical Properties of Metakaolinite-Based Geopolymers
por: Kohout, Jan, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_li1jrsvvcoen63vjuvupht9adk