Efficient biosynthesis of ethyl (R)-4-chloro-3-hydroxybutyrate using a stereoselective carbonyl reductase from Burkholderia gladioli

BACKGROUND: Ethyl (R)-4-chloro-3-hydroxybutyrate ((R)-CHBE) is a versatile chiral precursor for many pharmaceuticals. Although several biosynthesis strategies have been documented to convert ethyl 4-chloro-3-oxobutanoate (COBE) to (R)-CHBE, the catalytic efficiency and stereoselectivity are still to...

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Detalles Bibliográficos
Autores principales: Chen, Xiang, Liu, Zhi-Qiang, Lin, Chao-Ping, Zheng, Yu-Guo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5070160/
https://www.ncbi.nlm.nih.gov/pubmed/27756363
http://dx.doi.org/10.1186/s12896-016-0301-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5070160/
https://www.ncbi.nlm.nih.gov/pubmed/27756363
http://dx.doi.org/10.1186/s12896-016-0301-x

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