Cargando…

Reversal of Synapse Degeneration by Restoring Wnt Signaling in the Adult Hippocampus

Synapse degeneration occurs early in neurodegenerative diseases and correlates strongly with cognitive decline in Alzheimer’s disease (AD). The molecular mechanisms that trigger synapse vulnerability and those that promote synapse regeneration after substantial synaptic failure remain poorly underst...

Descripción completa

Detalles Bibliográficos
Autores principales:	Marzo, Aude, Galli, Soledad, Lopes, Douglas, McLeod, Faye, Podpolny, Marina, Segovia-Roldan, Margarita, Ciani, Lorenza, Purro, Silvia, Cacucci, Francesca, Gibb, Alasdair, Salinas, Patricia C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5070786/ https://www.ncbi.nlm.nih.gov/pubmed/27593374 http://dx.doi.org/10.1016/j.cub.2016.07.024

Ejemplares similares

Evaluation of Synapse Density in Hippocampal Rodent Brain Slices
por: McLeod, Faye, et al.
Publicado: (2017)

Wnt signalling tunes neurotransmitter release by directly targeting Synaptotagmin-1
por: Ciani, Lorenza, et al.
Publicado: (2015)

Striatal Synapse Degeneration and Dysfunction Are Reversed by Reactivation of Wnt Signaling
por: Galli, Soledad, et al.
Publicado: (2021)

Wnt Signaling Mediates LTP-Dependent Spine Plasticity and AMPAR Localization through Frizzled-7 Receptors
por: McLeod, Faye, et al.
Publicado: (2018)

Wnt Signaling Through Nitric Oxide Synthase Promotes the Formation of Multi-Innervated Spines
por: McLeod, Faye, et al.
Publicado: (2020)

Dysfunction of Wnt signaling and synaptic disassembly in neurodegenerative diseases
por: Purro, Silvia A., et al.
Publicado: (2014)

Wnt proteins as modulators of synaptic plasticity
por: McLeod, Faye, et al.
Publicado: (2018)

Deficient Wnt signalling triggers striatal synaptic degeneration and impaired motor behaviour in adult mice
por: Galli, Soledad, et al.
Publicado: (2014)

A genetic variant of the Wnt receptor LRP6 accelerates synapse degeneration during aging and in Alzheimer’s disease
por: Jones, Megan E., et al.
Publicado: (2023)

Signaling across the synapse: a role for Wnt and Dishevelled in presynaptic assembly and neurotransmitter release
por: Ahmad-Annuar, Azlina, et al.
Publicado: (2006)

Wnt-5a induces the conversion of silent to functional synapses in the hippocampus
por: Álvarez-Ferradas, Carla, et al.
Publicado: (2022)

Wnt-Frizzled Signaling Regulates Activity-Mediated Synapse Formation
por: Teo, Samuel, et al.
Publicado: (2021)

A divergent canonical WNT-signaling pathway regulates microtubule dynamics: Dishevelled signals locally to stabilize microtubules
por: Ciani, Lorenza, et al.
Publicado: (2004)

Disinhibition-Mediated LTP in the Hippocampus is Synapse Specific
por: Ormond, Jake, et al.
Publicado: (2011)

Microglia control glutamatergic synapses in the adult mouse hippocampus
por: Basilico, Bernadette, et al.
Publicado: (2021)

c-Jun N-terminal kinase (JNK) cooperates with Gsk3β to regulate Dishevelled-mediated microtubule stability
por: Ciani, Lorenza, et al.
Publicado: (2007)

Wnt signalling in the development of axon, dendrites and synapses
por: He, Chun-Wei, et al.
Publicado: (2018)

A Stereological Study of Synapse Number in the Epileptic Human Hippocampus
por: Alonso-Nanclares, Lidia, et al.
Publicado: (2011)

Reward behavior is regulated by the strength of hippocampus-nucleus accumbens synapses
por: LeGates, Tara A., et al.
Publicado: (2018)

Maternal Dietary Loads of Alpha-Tocopherol Increase Synapse Density and Glial Synaptic Coverage in the Hippocampus of Adult Offspring
por: Salucci, S., et al.
Publicado: (2014)

Reciprocal Regulation of Epileptiform Neuronal Oscillations and Electrical Synapses in the Rat Hippocampus
por: Kinjo, Erika R., et al.
Publicado: (2014)

Recurrent synapses and circuits in the CA3 region of the hippocampus: an associative network
por: Le Duigou, Caroline, et al.
Publicado: (2014)

Extracellular proteolysis in structural and functional plasticity of mossy fiber synapses in hippocampus
por: Wiera, Grzegorz, et al.
Publicado: (2015)

Neurexin-2: An inhibitory neurexin that restricts excitatory synapse formation in the hippocampus
por: Lin, Pei-Yi, et al.
Publicado: (2023)

Erratum: Recurrent synapses and circuits in the CA3 region of the hippocampus: an associative network
por: Le Duigou, Caroline, et al.
Publicado: (2014)

Selective Localization of Shanks to VGLUT1-Positive Excitatory Synapses in the Mouse Hippocampus
por: Heise, Christopher, et al.
Publicado: (2016)

Preferential pruning of inhibitory synapses by microglia contributes to alteration of the balance between excitatory and inhibitory synapses in the hippocampus in temporal lobe epilepsy
por: Fan, Jianchen, et al.
Publicado: (2023)

Reciprocal control of excitatory synapse numbers by Wnt and Wnt inhibitor PRR7 secreted on exosomes
por: Lee, Sang H., et al.
Publicado: (2018)

Epigenetic repression of Wnt receptors in AD: a role for Sirtuin2-induced H4K16ac deacetylation of Frizzled1 and Frizzled7 promoters
por: Palomer, Ernest, et al.
Publicado: (2022)

Estimation of the number of synapses in the hippocampus and brain-wide by volume electron microscopy and genetic labeling
por: Santuy, Andrea, et al.
Publicado: (2020)

Lactate induces synapse-specific potentiation on CA3 pyramidal cells of rat hippocampus
por: Herrera-López, Gabriel, et al.
Publicado: (2020)

Astrocytic Ephrin-B1 Controls Synapse Formation in the Hippocampus During Learning and Memory
por: Nguyen, Amanda Q., et al.
Publicado: (2020)

Microglia Depletion-Induced Remodeling of Extracellular Matrix and Excitatory Synapses in the Hippocampus of Adult Mice
por: Strackeljan, Luisa, et al.
Publicado: (2021)

Complement-associated loss of CA2 inhibitory synapses in the demyelinated hippocampus impairs memory
por: Ramaglia, Valeria, et al.
Publicado: (2021)

MDGA1 negatively regulates amyloid precursor protein–mediated synapse inhibition in the hippocampus
por: Kim, Jinhu, et al.
Publicado: (2022)

Downregulated Wnt/β-catenin signalling in the Down syndrome hippocampus
por: Granno, Simone, et al.
Publicado: (2019)

Mixed Electrical–Chemical Synapses in Adult Rat Hippocampus are Primarily Glutamatergic and Coupled by Connexin-36
por: Hamzei-Sichani, Farid, et al.
Publicado: (2012)

Preferential loss of dorsal-hippocampus synapses underlies memory impairments provoked by short, multimodal stress
por: Maras, P M, et al.
Publicado: (2014)

Long-term plasticity of inhibitory synapses in the hippocampus and spatial learning depends on matrix metalloproteinase 3
por: Wiera, Grzegorz, et al.
Publicado: (2020)

mTORC1 Signaling Pathway Mediates Chronic Stress-Induced Synapse Loss in the Hippocampus
por: Luo, Yu-Fei, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_skfnrk2lbdjj2teps8kssn2upb