Eosinophil peroxidase activates cells by HER2 receptor engagement and β1-integrin clustering with downstream MAPK cell signaling

Eosinophils account for 1–3% of peripheral blood leukocytes and accumulate at sites of allergic inflammation, where they play a pathogenic role. Studies have shown that treatment with mepolizumab (an anti-IL-5 monoclonal antibody) is beneficial to patients with severe eosinophilic asthma, however, t...

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Detalles Bibliográficos
Autores principales: Hennigan, Kerrie, Conroy, Paul J., Walsh, Marie-Therese, Amin, Mohamed, O'Kennedy, Richard, Ramasamy, Patmapriya, Gleich, Gerald J., Siddiqui, Zeshan, Glynn, Senan, McCabe, Olive, Mooney, Catherine, Harvey, Brian J., Costello, Richard W., McBryan, Jean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5070911/
https://www.ncbi.nlm.nih.gov/pubmed/27519953
http://dx.doi.org/10.1016/j.clim.2016.08.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5070911/
https://www.ncbi.nlm.nih.gov/pubmed/27519953
http://dx.doi.org/10.1016/j.clim.2016.08.009

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