Cargando…

IL‐12 and IL‐4 activate a CD39‐dependent intrinsic peripheral tolerance mechanism in CD8(+) T cells

Immune responses to protein antigens involve CD4(+) and CD8(+) T cells, which follow distinct programs of differentiation. Naïve CD8 T cells rapidly develop cytotoxic T‐cell (CTL) activity after T‐cell receptor stimulation, and we have previously shown that this is accompanied by suppressive activit...

Descripción completa

Detalles Bibliográficos
Autores principales:	Noble, Alistair, Mehta, Hema, Lovell, Andrew, Papaioannou, Eleftheria, Fairbanks, Lynette
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2016
Materias:	Immunomodulation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5071739/ https://www.ncbi.nlm.nih.gov/pubmed/26990545 http://dx.doi.org/10.1002/eji.201545939

Ejemplares similares

Glycogen synthase kinase-3 controls IL-10 expression in CD4(+) effector T-cell subsets through epigenetic modification of the IL-10 promoter
por: Hill, Elaine V, et al.
Publicado: (2015)

IL-33 attenuates the development of experimental autoimmune uveitis
por: Barbour, Mark, et al.
Publicado: (2014)

IL‐12/15/18‐preactivated NK cells suppress GvHD in a mouse model of mismatched hematopoietic cell transplantation
por: Hüber, Christian M., et al.
Publicado: (2015)

PD-1 modulates steady-state and infection-induced IL-10 production in vivo
por: McBerry, Cortez, et al.
Publicado: (2014)

Signal regulatory protein alpha (SIRPα) regulates the homeostasis of CD103(+)CD11b(+) DCs in the intestinal lamina propria
por: Scott, Charlotte L, et al.
Publicado: (2014)

Regulatory T cells can prevent memory CD8(+) T-cell-mediated rejection following polymorphonuclear cell depletion
por: Jones, Nick D, et al.
Publicado: (2010)

Enhanced immunogenicity of CTL antigens through mutation of the CD8 binding MHC class I invariant region
por: Wooldridge, Linda, et al.
Publicado: (2007)

Killing of myeloid APCs via HLA class I, CD2 and CD226 defines a novel mechanism of suppression by human Tr1 cells
por: Magnani, Chiara F, et al.
Publicado: (2011)

OX40 controls effector CD4(+) T-cell expansion, not follicular T helper cell generation in acute Listeria infection
por: Marriott, Clare L, et al.
Publicado: (2014)

Anti-CD4-mediated selection of Treg in vitro – in vitro suppression does not predict in vivo capacity to prevent graft rejection
por: Oliveira, Vanessa, et al.
Publicado: (2008)

Induction of transplantation tolerance converts potential effector T cells into graft-protective regulatory T cells
por: Francis, Ross S, et al.
Publicado: (2011)

The site of allergen expression in hematopoietic cells determines the degree and quality of tolerance induced through molecular chimerism
por: Baranyi, Ulrike, et al.
Publicado: (2013)

Progesterone promotes maternal–fetal tolerance by reducing human maternal T‐cell polyfunctionality and inducing a specific cytokine profile
por: Lissauer, David, et al.
Publicado: (2015)

Regulatory T cells inhibit Fas ligand-induced innate and adaptive tumour immunity
por: Simon, Anna Katharina, et al.
Publicado: (2007)

Absence of Rac1 and Rac3 GTPases in the nervous system hinders thymic, splenic and immune-competence development
por: Basso, Veronica, et al.
Publicado: (2011)

HIV-1 impairs in vitro priming of naïve T cells and gives rise to contact-dependent suppressor T cells
por: Che, Karlhans F, et al.
Publicado: (2010)

Exogenous IFN-γ ex vivo shapes the alloreactive T-cell repertoire by inhibition of Th17 responses and generation of functional Foxp3(+) regulatory T cells
por: Feng, Gang, et al.
Publicado: (2008)

Human β-defensin 3 has immunosuppressive activity in vitro and in vivo
por: Semple, Fiona, et al.
Publicado: (2010)

A homodimeric complex of HLA-G on normal trophoblast cells modulates antigen-presenting cells via LILRB1
por: Apps, Richard, et al.
Publicado: (2007)

Granulocyte-colony stimulating factor drives the in vitro differentiation of human dendritic cells that induce anergy in naïve T cells
por: Rossetti, Maura, et al.
Publicado: (2010)

Arginine depletion as a mechanism for the immune privilege of corneal allografts
por: Fu, Hongmei, et al.
Publicado: (2011)

Dendritic cell modification as a route to inhibiting corneal graft rejection by the indirect pathway of allorecognition
por: Khan, Adnan, et al.
Publicado: (2013)

Exacerbated experimental arthritis in Wiskott–Aldrich syndrome protein deficiency: Modulatory role of regulatory B cells
por: Bouma, Gerben, et al.
Publicado: (2014)

Human β-defensin 3 affects the activity of pro-inflammatory pathways associated with MyD88 and TRIF
por: Semple, Fiona, et al.
Publicado: (2011)

HLA class I downregulation is associated with enhanced NK‐cell killing of melanoma cells with acquired drug resistance to BRAF inhibitors
por: Sottile, Rosa, et al.
Publicado: (2015)

Exposure to inflammatory cytokines selectively limits GM-CSF production by induced T regulatory cells
por: Reynolds, Ben C, et al.
Publicado: (2014)

Interleukin 17 inhibits progenitor cells in rheumatoid arthritis cartilage
por: Schminke, Boris, et al.
Publicado: (2015)

NFATc1 deficiency in T cells protects mice from experimental autoimmune encephalomyelitis
por: Reppert, Sarah, et al.
Publicado: (2015)

Non‐glycosidic compounds can stimulate both human and mouse iNKT cells
por: Jukes, John‐Paul, et al.
Publicado: (2016)

4‐1BB costimulation promotes bystander activation of human CD8 T cells
por: Reithofer, Manuel, et al.
Publicado: (2020)

The soluble cytoplasmic tail of CD45 (ct‐CD45) in human plasma contributes to keep T cells in a quiescent state
por: Puck, Alexander, et al.
Publicado: (2016)

Chimeric antigen receptor‐modified human regulatory T cells that constitutively express IL‐10 maintain their phenotype and are potently suppressive
por: Mohseni, Yasmin R., et al.
Publicado: (2021)

CD73 contributes to anti‐inflammatory properties of afferent lymphatic endothelial cells in humans and mice
por: Eichin, Dominik, et al.
Publicado: (2020)

Termination of CD40L co‐stimulation promotes human B cell differentiation into antibody‐secreting cells
por: Marsman, Casper, et al.
Publicado: (2022)

Human dendritic cells activated with MV130 induce Th1, Th17 and IL‐10 responses via RIPK2 and MyD88 signalling pathways
por: Cirauqui, Cristina, et al.
Publicado: (2017)

Anti‐TNF treatment negatively regulates human CD4(+) T‐cell activation and maturation in vitro, but does not confer an anergic or suppressive phenotype
por: Povoleri, Giovanni A. M., et al.
Publicado: (2019)

Mesenteric lymph node stromal cell‐derived extracellular vesicles contribute to peripheral de novo induction of Foxp3(+) regulatory T cells
por: Pasztoi, Maria, et al.
Publicado: (2017)

Peripheral human CD4(+)CD8(+) T lymphocytes exhibit a memory phenotype and enhanced responses to IL-2, IL-7 and IL-15
por: Clénet, Marie-Laure, et al.
Publicado: (2017)

IL-4 prevents adenosine-mediated immunoregulation by inhibiting CD39 expression
por: Fang, Fengqin, et al.
Publicado: (2022)

Trained Immunity of IL-12-, IL-15-, and IL-18-Induced CD(3)+CD(56)+ NKT-Like Cells
por: Zhu, Siyu, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_lv39lp8hnmshjflhif0pufml6n