Antigen-affinity controls pre-germinal centser B cell selection by promoting Mcl-1 induction through BAFF receptor signaling

Upon antigen encounter, the responsive B cell pool undergoes stringent selection which eliminates cells with low B cell receptor (BCR) affinity. Already before formation of the germinal center, activated B cells of low-affinity are negatively selected in a process that is molecularly not well unders...

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Detalles Bibliográficos
Autores principales: Wensveen, Felix M., Slinger, Erik, van Attekum, Martijn HA, Brink, Robert, Eldering, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5071843/
https://www.ncbi.nlm.nih.gov/pubmed/27762293
http://dx.doi.org/10.1038/srep35673

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5071843/
https://www.ncbi.nlm.nih.gov/pubmed/27762293
http://dx.doi.org/10.1038/srep35673

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