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Engineering prokaryotic channels for control of mammalian tissue excitability
The ability to directly enhance electrical excitability of human cells is hampered by the lack of methods to efficiently overexpress large mammalian voltage-gated sodium channels (VGSC). Here we describe the use of small prokaryotic sodium channels (BacNa(v)) to create de novo excitable human tissue...
Autores principales: | Nguyen, Hung X., Kirkton, Robert D., Bursac, Nenad |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5071848/ https://www.ncbi.nlm.nih.gov/pubmed/27752065 http://dx.doi.org/10.1038/ncomms13132 |
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