Cargando…
A unique peptide deformylase platform to rationally design and challenge novel active compounds
Peptide deformylase (PDF) is considered an excellent target to develop antibiotics. We have performed an extensive characterization of a new PDF from the pathogen Streptococcus agalactiae, showing properties similar to other known PDFs. S. agalactiae PDF could be used as PDF prototype as it allowed...
Autores principales: | Fieulaine, Sonia, Alves de Sousa, Rodolphe, Maigre, Laure, Hamiche, Karim, Alimi, Mickael, Bolla, Jean-Michel, Taleb, Abbass, Denis, Alexis, Pagès, Jean-Marie, Artaud, Isabelle, Meinnel, Thierry, Giglione, Carmela |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5071857/ https://www.ncbi.nlm.nih.gov/pubmed/27762275 http://dx.doi.org/10.1038/srep35429 |
Ejemplares similares
-
Corrigendum: A unique peptide deformylase platform to rationally design and challenge novel active compounds
por: Fieulaine, Sonia, et al.
Publicado: (2017) -
Trapping Conformational States Along Ligand-Binding Dynamics of Peptide Deformylase: The Impact of Induced Fit on Enzyme Catalysis
por: Fieulaine, Sonia, et al.
Publicado: (2011) -
New Antibiotic Molecules: Bypassing the Membrane Barrier of Gram Negative Bacteria Increases the Activity of Peptide Deformylase Inhibitors
por: Mamelli, Laurent, et al.
Publicado: (2009) -
The C-terminal residue of phage Vp16 PDF, the smallest peptide deformylase, acts as an offset element locking the active conformation
por: Grzela, Renata, et al.
Publicado: (2017) -
EnCOUNTer: a parsing tool to uncover the mature N-terminus of organelle-targeted proteins in complex samples
por: Bienvenut, Willy Vincent, et al.
Publicado: (2017)