Platelet-Derived Short-Chain Polyphosphates Enhance the Inactivation of Tissue Factor Pathway Inhibitor by Activated Coagulation Factor XI

INTRODUCTION: Factor (F) XI supports both normal human hemostasis and pathological thrombosis. Activated FXI (FXIa) promotes thrombin generation by enzymatic activation of FXI, FIX, FX, and FV, and inactivation of alpha tissue factor pathway inhibitor (TFPIα), in vitro. Some of these reactions are n...

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Detalles Bibliográficos
Autores principales: Puy, Cristina, Tucker, Erik I., Ivanov, Ivan S., Gailani, David, Smith, Stephanie A., Morrissey, James H., Gruber, András, McCarty, Owen J. T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5072614/
https://www.ncbi.nlm.nih.gov/pubmed/27764259
http://dx.doi.org/10.1371/journal.pone.0165172

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5072614/
https://www.ncbi.nlm.nih.gov/pubmed/27764259
http://dx.doi.org/10.1371/journal.pone.0165172

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