Respiratory syncytial virus a and b display different temporal patterns in a 4-year prospective cross-sectional study among children with acute respiratory infection in a tropical city

Respiratory syncytial virus (RSV) is one of the most common etiological agents of childhood respiratory infections globally. Information on seasonality of different antigenic groups is scarce. We aimed to describe the frequency, seasonality, and age of children infected by RSV antigenic groups A (RS...

Descripción completa

Detalles Bibliográficos
Autores principales: Bouzas, Maiara L., Oliveira, Juliana R., Fukutani, Kiyoshi F., Borges, Igor C., Barral, Aldina, Van der Gucht, Winke, Wollants, Elke, Van Ranst, Marc, de Oliveira, Camila I., Van Weyenbergh, Johan, Nascimento-Carvalho, Cristiana M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5072971/
https://www.ncbi.nlm.nih.gov/pubmed/27741144
http://dx.doi.org/10.1097/MD.0000000000005142
_version_ 1782461495636918272
author Bouzas, Maiara L.
Oliveira, Juliana R.
Fukutani, Kiyoshi F.
Borges, Igor C.
Barral, Aldina
Van der Gucht, Winke
Wollants, Elke
Van Ranst, Marc
de Oliveira, Camila I.
Van Weyenbergh, Johan
Nascimento-Carvalho, Cristiana M.
author_facet Bouzas, Maiara L.
Oliveira, Juliana R.
Fukutani, Kiyoshi F.
Borges, Igor C.
Barral, Aldina
Van der Gucht, Winke
Wollants, Elke
Van Ranst, Marc
de Oliveira, Camila I.
Van Weyenbergh, Johan
Nascimento-Carvalho, Cristiana M.
author_sort Bouzas, Maiara L.
collection PubMed
description Respiratory syncytial virus (RSV) is one of the most common etiological agents of childhood respiratory infections globally. Information on seasonality of different antigenic groups is scarce. We aimed to describe the frequency, seasonality, and age of children infected by RSV antigenic groups A (RSVA) and B (RSVB) among children with ARI in a 4-year period. Children (6–23 months old) with respiratory infection for ≤7 days were enrolled in a prospective cross-sectional study, from September, 2009 to October, 2013, in Salvador, in a tropical region of Brazil. Upon recruitment, demographic, clinical data, and nasopharyngeal aspirates (NPA) were collected. A multiplex quantitative real-time polymerase chain reaction (RT-PCR) with a group-specific primer and probeset for RSVA and RSVB was used. Seasonal distribution of infection by RSV different antigenic groups was evaluated by Prais-Wisten regression. Of 560 cases, the mean age was 11.4 ± 4.5 months and there were 287 (51.3%) girls. Overall, RSV was detected in 139 (24.8%; 95% CI: 21.4%–28.5%) cases, RSVA in 74 (13.2%; 95% CI: 10.6%–16.2%) cases, and RSVB in 67 (12.0%; 95% CI: 9.5%–14.9%) cases. Two (0.4%; 95% CI: 0.06%–1.2%) cases had coinfection. RSVA frequency was 9.6%, 18.4%, 21.6%, and 3.1% in 2010, 2011, 2012, and 2013, respectively. RSVB frequency was 19.2%, 0.7%, 1.4%, and 35.4% in the same years. RSVA was more frequently found from August to January than February to July (18.2% vs. 6.4%, P < 0.001). RSVB was more frequently found (P < 0.001) between March and June (36.0%) than July to October (1.0%) or November to February (1.6%). RSVB infection showed seasonal distribution and positive association with humidity (P = 0.02) whereas RSVA did not. RSVA was more common among children ≥1-year-old (17.8% vs. 1.8%; P = 0.02), as opposed to RSVB (11.5% vs. 12.2%; P = 0.8). One quarter of patients had RSV infection. RSVA compromised more frequently children aged ≥1 year. RSVA predominated in 2011 and 2012 whereas RSVB predominated in 2010 and 2013. In regard to months, RSVA was more frequent from August to January whereas RSVB was more often detected between March and June. Markedly different monthly as well as yearly patterns for RSVA and RSVB reveal independent RSV antigenic groups’ epidemics.
format Online
Article
Text
id pubmed-5072971
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Wolters Kluwer Health
record_format MEDLINE/PubMed
spelling pubmed-50729712016-10-28 Respiratory syncytial virus a and b display different temporal patterns in a 4-year prospective cross-sectional study among children with acute respiratory infection in a tropical city Bouzas, Maiara L. Oliveira, Juliana R. Fukutani, Kiyoshi F. Borges, Igor C. Barral, Aldina Van der Gucht, Winke Wollants, Elke Van Ranst, Marc de Oliveira, Camila I. Van Weyenbergh, Johan Nascimento-Carvalho, Cristiana M. Medicine (Baltimore) 6200 Respiratory syncytial virus (RSV) is one of the most common etiological agents of childhood respiratory infections globally. Information on seasonality of different antigenic groups is scarce. We aimed to describe the frequency, seasonality, and age of children infected by RSV antigenic groups A (RSVA) and B (RSVB) among children with ARI in a 4-year period. Children (6–23 months old) with respiratory infection for ≤7 days were enrolled in a prospective cross-sectional study, from September, 2009 to October, 2013, in Salvador, in a tropical region of Brazil. Upon recruitment, demographic, clinical data, and nasopharyngeal aspirates (NPA) were collected. A multiplex quantitative real-time polymerase chain reaction (RT-PCR) with a group-specific primer and probeset for RSVA and RSVB was used. Seasonal distribution of infection by RSV different antigenic groups was evaluated by Prais-Wisten regression. Of 560 cases, the mean age was 11.4 ± 4.5 months and there were 287 (51.3%) girls. Overall, RSV was detected in 139 (24.8%; 95% CI: 21.4%–28.5%) cases, RSVA in 74 (13.2%; 95% CI: 10.6%–16.2%) cases, and RSVB in 67 (12.0%; 95% CI: 9.5%–14.9%) cases. Two (0.4%; 95% CI: 0.06%–1.2%) cases had coinfection. RSVA frequency was 9.6%, 18.4%, 21.6%, and 3.1% in 2010, 2011, 2012, and 2013, respectively. RSVB frequency was 19.2%, 0.7%, 1.4%, and 35.4% in the same years. RSVA was more frequently found from August to January than February to July (18.2% vs. 6.4%, P < 0.001). RSVB was more frequently found (P < 0.001) between March and June (36.0%) than July to October (1.0%) or November to February (1.6%). RSVB infection showed seasonal distribution and positive association with humidity (P = 0.02) whereas RSVA did not. RSVA was more common among children ≥1-year-old (17.8% vs. 1.8%; P = 0.02), as opposed to RSVB (11.5% vs. 12.2%; P = 0.8). One quarter of patients had RSV infection. RSVA compromised more frequently children aged ≥1 year. RSVA predominated in 2011 and 2012 whereas RSVB predominated in 2010 and 2013. In regard to months, RSVA was more frequent from August to January whereas RSVB was more often detected between March and June. Markedly different monthly as well as yearly patterns for RSVA and RSVB reveal independent RSV antigenic groups’ epidemics. Wolters Kluwer Health 2016-10-14 /pmc/articles/PMC5072971/ /pubmed/27741144 http://dx.doi.org/10.1097/MD.0000000000005142 Text en Copyright © 2016 the Author(s). Published by Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NoDerivatives License 4.0, which allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author. http://creativecommons.org/licenses/by-nd/4.0
spellingShingle 6200
Bouzas, Maiara L.
Oliveira, Juliana R.
Fukutani, Kiyoshi F.
Borges, Igor C.
Barral, Aldina
Van der Gucht, Winke
Wollants, Elke
Van Ranst, Marc
de Oliveira, Camila I.
Van Weyenbergh, Johan
Nascimento-Carvalho, Cristiana M.
Respiratory syncytial virus a and b display different temporal patterns in a 4-year prospective cross-sectional study among children with acute respiratory infection in a tropical city
title Respiratory syncytial virus a and b display different temporal patterns in a 4-year prospective cross-sectional study among children with acute respiratory infection in a tropical city
title_full Respiratory syncytial virus a and b display different temporal patterns in a 4-year prospective cross-sectional study among children with acute respiratory infection in a tropical city
title_fullStr Respiratory syncytial virus a and b display different temporal patterns in a 4-year prospective cross-sectional study among children with acute respiratory infection in a tropical city
title_full_unstemmed Respiratory syncytial virus a and b display different temporal patterns in a 4-year prospective cross-sectional study among children with acute respiratory infection in a tropical city
title_short Respiratory syncytial virus a and b display different temporal patterns in a 4-year prospective cross-sectional study among children with acute respiratory infection in a tropical city
title_sort respiratory syncytial virus a and b display different temporal patterns in a 4-year prospective cross-sectional study among children with acute respiratory infection in a tropical city
topic 6200
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5072971/
https://www.ncbi.nlm.nih.gov/pubmed/27741144
http://dx.doi.org/10.1097/MD.0000000000005142
work_keys_str_mv AT bouzasmaiaral respiratorysyncytialvirusaandbdisplaydifferenttemporalpatternsina4yearprospectivecrosssectionalstudyamongchildrenwithacuterespiratoryinfectioninatropicalcity
AT oliveirajulianar respiratorysyncytialvirusaandbdisplaydifferenttemporalpatternsina4yearprospectivecrosssectionalstudyamongchildrenwithacuterespiratoryinfectioninatropicalcity
AT fukutanikiyoshif respiratorysyncytialvirusaandbdisplaydifferenttemporalpatternsina4yearprospectivecrosssectionalstudyamongchildrenwithacuterespiratoryinfectioninatropicalcity
AT borgesigorc respiratorysyncytialvirusaandbdisplaydifferenttemporalpatternsina4yearprospectivecrosssectionalstudyamongchildrenwithacuterespiratoryinfectioninatropicalcity
AT barralaldina respiratorysyncytialvirusaandbdisplaydifferenttemporalpatternsina4yearprospectivecrosssectionalstudyamongchildrenwithacuterespiratoryinfectioninatropicalcity
AT vanderguchtwinke respiratorysyncytialvirusaandbdisplaydifferenttemporalpatternsina4yearprospectivecrosssectionalstudyamongchildrenwithacuterespiratoryinfectioninatropicalcity
AT wollantselke respiratorysyncytialvirusaandbdisplaydifferenttemporalpatternsina4yearprospectivecrosssectionalstudyamongchildrenwithacuterespiratoryinfectioninatropicalcity
AT vanranstmarc respiratorysyncytialvirusaandbdisplaydifferenttemporalpatternsina4yearprospectivecrosssectionalstudyamongchildrenwithacuterespiratoryinfectioninatropicalcity
AT deoliveiracamilai respiratorysyncytialvirusaandbdisplaydifferenttemporalpatternsina4yearprospectivecrosssectionalstudyamongchildrenwithacuterespiratoryinfectioninatropicalcity
AT vanweyenberghjohan respiratorysyncytialvirusaandbdisplaydifferenttemporalpatternsina4yearprospectivecrosssectionalstudyamongchildrenwithacuterespiratoryinfectioninatropicalcity
AT nascimentocarvalhocristianam respiratorysyncytialvirusaandbdisplaydifferenttemporalpatternsina4yearprospectivecrosssectionalstudyamongchildrenwithacuterespiratoryinfectioninatropicalcity
AT respiratorysyncytialvirusaandbdisplaydifferenttemporalpatternsina4yearprospectivecrosssectionalstudyamongchildrenwithacuterespiratoryinfectioninatropicalcity