Cargando…

HOXA5 determines cell fate transition and impedes tumor initiation and progression in breast cancer through regulation of E-cadherin and CD24

Loss of HOXA5 expression occurs frequently in breast cancer and correlates with higher pathological grade and poorer disease outcome. However, how HOX proteins drive differentiation in mammalian cells is poorly understood. In this paper, we investigated cellular and molecular consequences of loss of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Teo, Wei Wen, Merino, Vanessa F., Cho, Soonweng, Korangath, Preethi, Liang, Xiaohui, Wu, Ren-chin, Neumann, Neil M., Ewald, Andrew J., Sukumar, Saraswati
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5073039/ https://www.ncbi.nlm.nih.gov/pubmed/27157614 http://dx.doi.org/10.1038/onc.2016.95

Ejemplares similares

HEYL Regulates Neoangiogenesis Through Overexpression in Both Breast Tumor Epithelium and Endothelium
por: Han, Liangfeng, et al.
Publicado: (2021)

Inhibitors of STAT3, β‐catenin, and IGF‐1R sensitize mouse PIK3CA‐mutant breast cancer to PI3K inhibitors
por: Merino, Vanessa F., et al.
Publicado: (2017)

Intraductal administration of transferrin receptor-targeted immunotoxin clears ductal carcinoma in situ in mouse models of breast cancer—a preclinical study
por: Wang, Guannan, et al.
Publicado: (2022)

Induction of cell cycle arrest and inflammatory genes by combined treatment with epigenetic, differentiating, and chemotherapeutic agents in triple-negative breast cancer
por: Merino, Vanessa F., et al.
Publicado: (2018)

HoxA Genes and the Fin-to-Limb Transition in Vertebrates
por: Leite-Castro, João, et al.
Publicado: (2016)

Subtype-specific overexpression of the Rac-GEF P-REX1 in breast cancer is associated with promoter hypomethylation
por: Barrio-Real, Laura, et al.
Publicado: (2014)

Combining the strength of genomics, nanoparticle technology, and direct intraductal delivery for breast cancer treatment
por: Teo, Wei Wen, et al.
Publicado: (2014)

Medial HOXA genes demarcate haematopoietic stem cell fate during human development
por: Dou, Diana R., et al.
Publicado: (2016)

HOXA7, HOXA9, and HOXA10 are differentially expressed in clival and sacral chordomas
por: Jäger, Daniela, et al.
Publicado: (2017)

Genetic and phenotypic continuum of HOXA genes: A case with double HOXA9/HOXA13 mutations
por: Jaouadi, Hager, et al.
Publicado: (2023)

The E-Cadherin and N-Cadherin Switch in Epithelial-to-Mesenchymal Transition: Signaling, Therapeutic Implications, and Challenges
por: Loh, Chin-Yap, et al.
Publicado: (2019)

Molecular Characterization of HOXA2 and HOXA3 Binding Properties
por: Mallen, Joshua, et al.
Publicado: (2021)

HOXA9 promotes homotypic and heterotypic cell interactions that facilitate ovarian cancer dissemination via its induction of P-cadherin
por: Ko, Song Yi, et al.
Publicado: (2014)

MicroRNA-638 inhibits the progression of breast cancer through targeting HOXA9 and suppressing Wnt/β-cadherin pathway
por: Xu, Qian, et al.
Publicado: (2021)

Breast-Specific Epigenetic Regulation of DeltaNp73 and Its Role in DNA-Damage-Response of BRCA1-Mutated Human Mammary Epithelial Cells
por: Avraham, Ayelet, et al.
Publicado: (2020)

Study of Promoter Methylation Patterns of HOXA2, HOXA5, and HOXA6 and Its Clinicopathological Characteristics in Colorectal Cancer
por: Li, Daojiang, et al.
Publicado: (2019)

Comprehensive Landscape of HOXA2, HOXA9, and HOXA10 as Potential Biomarkers for Predicting Progression and Prognosis in Prostate Cancer
por: Song, Yan-ping, et al.
Publicado: (2022)

Tissue Specific DNA Methylation in Normal Human Breast Epithelium and in Breast Cancer
por: Avraham, Ayelet, et al.
Publicado: (2014)

Expression Landscape and Functional Roles of HOXA4 and HOXA5 in Lung Adenocarcinoma
por: Gao, Li, et al.
Publicado: (2022)

Reprogramming the fate of human glioma cells to impede brain tumor development
por: Su, Z, et al.
Publicado: (2014)

E-cadherin focuses protrusion formation at the front of migrating cells by impeding actin flow
por: Grimaldi, Cecilia, et al.
Publicado: (2020)

+HOXA10-AS Promotes Malignant Phenotypes of Gastric Cancer via Upregulating HOXA10
por: Cao, Fengyu, et al.
Publicado: (2022)

A Predictive Pharmacokinetic Model for Immune Cell-Mediated Uptake and Retention of Nanoparticles in Tumors
por: Sousa-Junior, Ailton, et al.
Publicado: (2022)

Characteristics of bladder transitional cell carcinoma with E-cadherin and N-cadherin double-negative expression
por: LUO, YANG, et al.
Publicado: (2016)

Retracted: +HOXA10-AS Promotes Malignant Phenotypes of Gastric Cancer via Upregulating HOXA10
por: Methods in Medicine, Computational and Mathematical
Publicado: (2023)

Phytochemicals in Cancer Prevention and Therapy
por: Pratheeshkumar, Poyil, et al.
Publicado: (2015)

N-Cadherin adhesive interactions modulate matrix mechanosensing and fate commitment of mesenchymal stem cells
por: Cosgrove, Brian D., et al.
Publicado: (2016)

BRCA1: linking HOX to breast cancer suppression
por: Jin, Kideok, et al.
Publicado: (2010)

A pivotal role for HOXB7 protein in endocrine resistant breast cancer
por: Jin, Kideok, et al.
Publicado: (2015)

E-cadherin on epithelial–mesenchymal transition in thyroid cancer
por: Zhu, Xiaoyu, et al.
Publicado: (2021)

Nanoparticle interactions with immune cells dominate tumor retention and induce T cell–mediated tumor suppression in models of breast cancer
por: Korangath, Preethi, et al.
Publicado: (2020)

Comparative genomics of chondrichthyan Hoxa clusters
por: Mulley, John F, et al.
Publicado: (2009)

No evidence of involvement of E-cadherin in cell fate specification or the segregation of Epi and PrE in mouse blastocysts
por: Filimonow, Katarzyna, et al.
Publicado: (2019)

HOXA‑AS3 induces tumor progression through the epithelial‑mesenchymal transition pathway in epithelial ovarian cancer
por: Eoh, Kyung Jin, et al.
Publicado: (2023)

Effect of intramural myomectomy on endometrial HOXA10 and HOXA11 mRNA expression at the time of implantation window
por: Alizadeh, Zohreh, et al.
Publicado: (2013)

Hoxa9 and Hoxa10 induce CML myeloid blast crisis development through activation of Myb expression
por: Negi, Vijay, et al.
Publicado: (2017)

HOXA11 antisense long noncoding RNA (HOXA11‐AS): A promising lncRNA in human cancers
por: Lu, Cheng‐Wei, et al.
Publicado: (2018)

LncHOXA10 drives liver TICs self-renewal and tumorigenesis via HOXA10 transcription activation
por: Shao, Ming, et al.
Publicado: (2018)

Polycomb repressor complex 2 regulates HOXA9 and HOXA10, activating ID2 in NK/T-cell lines
por: Nagel, Stefan, et al.
Publicado: (2010)

Translation inhibitory elements from Hoxa3 and Hoxa11 mRNAs use uORFs for translation inhibition
por: Alghoul, Fatima, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_q1fad3eatq46am3ikrgfg8ck98