Direct and indirect mechanisms of KLK4 inhibition revealed by structure and dynamics

The kallikrein-related peptidase (KLK) family of proteases is involved in many aspects of human health and disease. One member of this family, KLK4, has been implicated in cancer development and metastasis. Understanding mechanisms of inactivation are critical to developing selective KLK4 inhibitors...

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Detalles Bibliográficos
Autores principales: Riley, Blake T., Ilyichova, Olga, Costa, Mauricio G. S., Porebski, Benjamin T., de Veer, Simon J., Swedberg, Joakim E., Kass, Itamar, Harris, Jonathan M., Hoke, David E., Buckle, Ashley M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5073354/
https://www.ncbi.nlm.nih.gov/pubmed/27767076
http://dx.doi.org/10.1038/srep35385

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5073354/
https://www.ncbi.nlm.nih.gov/pubmed/27767076
http://dx.doi.org/10.1038/srep35385

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