Therapeutic effect of berberine on TDP-43-related pathogenesis in FTLD and ALS

BACKGROUND: In the central nervous system regions of the sporadic and familial FTLD and ALS patients, TDP-43 has been identified as the major component of UBIs inclusions which is abnormally hyperphosphorylated, ubiquitinated, and cleaved into C-terminal fragments to form detergent-insoluble aggrega...

Descripción completa

Detalles Bibliográficos
Autores principales: Chang, Cheng-Fu, Lee, Yi-Chao, Lee, Kuen-Haur, Lin, Hui-Ching, Chen, Chia-Ling, Shen, Che-Kun James, Huang, Chi-Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5073438/
https://www.ncbi.nlm.nih.gov/pubmed/27769241
http://dx.doi.org/10.1186/s12929-016-0290-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5073438/
https://www.ncbi.nlm.nih.gov/pubmed/27769241
http://dx.doi.org/10.1186/s12929-016-0290-z

Ejemplares similares