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Therapeutic effect of berberine on TDP-43-related pathogenesis in FTLD and ALS

BACKGROUND: In the central nervous system regions of the sporadic and familial FTLD and ALS patients, TDP-43 has been identified as the major component of UBIs inclusions which is abnormally hyperphosphorylated, ubiquitinated, and cleaved into C-terminal fragments to form detergent-insoluble aggrega...

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Detalles Bibliográficos
Autores principales:	Chang, Cheng-Fu, Lee, Yi-Chao, Lee, Kuen-Haur, Lin, Hui-Ching, Chen, Chia-Ling, Shen, Che-Kun James, Huang, Chi-Chen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5073438/ https://www.ncbi.nlm.nih.gov/pubmed/27769241 http://dx.doi.org/10.1186/s12929-016-0290-z

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