Improving sensitivity of linear regression-based cell type-specific differential expression deconvolution with per-gene vs. global significance threshold

BACKGROUND: The goal of many human disease-oriented studies is to detect molecular mechanisms different between healthy controls and patients. Yet, commonly used gene expression measurements from blood samples suffer from variability of cell composition. This variability hinders the detection of dif...

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Detalles Bibliográficos
Autores principales: Glass, Edmund R., Dozmorov, Mikhail G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Proceedings
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5073979/
https://www.ncbi.nlm.nih.gov/pubmed/27766949
http://dx.doi.org/10.1186/s12859-016-1226-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5073979/
https://www.ncbi.nlm.nih.gov/pubmed/27766949
http://dx.doi.org/10.1186/s12859-016-1226-z

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