Novel minimal physiologically-based model for the prediction of passive tubular reabsorption and renal excretion clearance

PURPOSE: Develop a minimal mechanistic model based on in vitro–in vivo extrapolation (IVIVE) principles to predict extent of passive tubular reabsorption. Assess the ability of the model developed to predict extent of passive tubular reabsorption (F(reab)) and renal excretion clearance (CL(R)) from...

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Detalles Bibliográficos
Autores principales: Scotcher, Daniel, Jones, Christopher, Rostami-Hodjegan, Amin, Galetin, Aleksandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science B.V 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5074076/
https://www.ncbi.nlm.nih.gov/pubmed/27033147
http://dx.doi.org/10.1016/j.ejps.2016.03.018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5074076/
https://www.ncbi.nlm.nih.gov/pubmed/27033147
http://dx.doi.org/10.1016/j.ejps.2016.03.018

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