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Novel minimal physiologically-based model for the prediction of passive tubular reabsorption and renal excretion clearance
PURPOSE: Develop a minimal mechanistic model based on in vitro–in vivo extrapolation (IVIVE) principles to predict extent of passive tubular reabsorption. Assess the ability of the model developed to predict extent of passive tubular reabsorption (F(reab)) and renal excretion clearance (CL(R)) from...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Science B.V
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5074076/ https://www.ncbi.nlm.nih.gov/pubmed/27033147 http://dx.doi.org/10.1016/j.ejps.2016.03.018 |