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Transfer of Electrophilic NH Using Convenient Sources of Ammonia: Direct Synthesis of NH Sulfoximines from Sulfoxides

A new system for NH transfer is developed for the preparation of sulfoximines, which are emerging as valuable motifs for drug discovery. The protocol employs readily available sources of nitrogen without the requirement for either preactivation or for metal catalysts. Mixing ammonium salts with diac...

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Detalles Bibliográficos
Autores principales: Zenzola, Marina, Doran, Robert, Degennaro, Leonardo, Luisi, Renzo, Bull, James A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5074267/
https://www.ncbi.nlm.nih.gov/pubmed/27126053
http://dx.doi.org/10.1002/anie.201602320