Screening and Development of New Inhibitors of FtsZ from M. Tuberculosis

A variety of commercial analogs and a newer series of Sulindac derivatives were screened for inhibition of M. tuberculosis (Mtb) in vitro and specifically as inhibitors of the essential mycobacterial tubulin homolog, FtsZ. Due to the ease of preparing diverse analogs and a favorable in vivo pharmaco...

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Detalles Bibliográficos
Autores principales: Mathew, Bini, Hobrath, Judith Varady, Ross, Larry, Connelly, Michele C., Lofton, Hava, Rajagopalan, Malini, Guy, R. Kiplin, Reynolds, Robert C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5074515/
https://www.ncbi.nlm.nih.gov/pubmed/27768711
http://dx.doi.org/10.1371/journal.pone.0164100

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5074515/
https://www.ncbi.nlm.nih.gov/pubmed/27768711
http://dx.doi.org/10.1371/journal.pone.0164100

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