Population Pharmacokinetics and Dosing Regimen Optimization of Meropenem in Cerebrospinal Fluid and Plasma in Patients with Meningitis after Neurosurgery

Meropenem is used to manage postneurosurgical meningitis, but its population pharmacokinetics (PPK) in plasma and cerebrospinal fluid (CSF) in this patient group are not well-known. Our aims were to (i) characterize meropenem PPK in plasma and CSF and (ii) recommend favorable dosing regimens in post...

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Detalles Bibliográficos
Autores principales: Lu, Cheng, Zhang, Yuyi, Chen, Mingyu, Zhong, Ping, Chen, Yuancheng, Yu, Jicheng, Wu, Xiaojie, Wu, Jufang, Zhang, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2016
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075067/
https://www.ncbi.nlm.nih.gov/pubmed/27572392
http://dx.doi.org/10.1128/AAC.00997-16

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075067/
https://www.ncbi.nlm.nih.gov/pubmed/27572392
http://dx.doi.org/10.1128/AAC.00997-16

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