Steroid resistance in COPD is associated with impaired molecular chaperone Hsp90 expression by pro-inflammatory lymphocytes

BACKGROUND: Corticosteroid resistance is a major barrier to effective treatment of COPD. We have shown that the resistance is associated with decreased expression of glucocorticoid receptor (GCR) by senescent CD28nullCD8+ pro-inflammatory lymphocytes in peripheral blood of COPD patients. GCR must be...

Descripción completa

Detalles Bibliográficos
Autores principales: Hodge, Greg, Roscioli, Eugene, Jersmann, Hubertus, Tran, Hai B., Holmes, Mark, Reynolds, Paul N., Hodge, Sandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075183/
https://www.ncbi.nlm.nih.gov/pubmed/27769261
http://dx.doi.org/10.1186/s12931-016-0450-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075183/
https://www.ncbi.nlm.nih.gov/pubmed/27769261
http://dx.doi.org/10.1186/s12931-016-0450-4

Ejemplares similares