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A DNA vaccine targeting TcdA and TcdB induces protective immunity against Clostridium difficile
BACKGROUND: Clostridium difficile-associated disease (CDAD) constitutes a great majority of hospital diarrhea cases in industrialized countries and is induced by two types of large toxin molecules: toxin A (TcdA) and toxin B (TcdB). Development of immunotherapeutic approaches, either active or passi...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075199/ https://www.ncbi.nlm.nih.gov/pubmed/27770789 http://dx.doi.org/10.1186/s12879-016-1924-1 |