A small molecule targeting protein translation does not rescue spatial learning and memory deficits in the hAPP-J20 mouse model of Alzheimer’s disease

A small molecule named ISRIB has recently been described to enhance memory in rodents. In this study we aimed to test whether ISRIB would reverse learning and memory deficits in the J20 mouse model of human amyloid precursor protein (hAPP) overexpression, a model that simulates many aspects of Alzhe...

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Detalles Bibliográficos
Autores principales: Johnson, Erik C.B., Kang, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2016
Materias:
Animal Behavior
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075699/
https://www.ncbi.nlm.nih.gov/pubmed/27781164
http://dx.doi.org/10.7717/peerj.2565

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075699/
https://www.ncbi.nlm.nih.gov/pubmed/27781164
http://dx.doi.org/10.7717/peerj.2565

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