αβ T cell receptor germline CDR regions moderate contact with MHC ligands and regulate peptide cross-reactivity

αβ T cells respond to peptide epitopes presented by major histocompatibility complex (MHC) molecules. The role of T cell receptor (TCR) germline complementarity determining regions (CDR1 and 2) in MHC restriction is not well understood. Here, we examine T cell development, MHC restriction and antige...

Descripción completa

Detalles Bibliográficos
Autores principales: Attaf, Meriem, Holland, Stephan J., Bartok, Istvan, Dyson, Julian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075794/
https://www.ncbi.nlm.nih.gov/pubmed/27775030
http://dx.doi.org/10.1038/srep35006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075794/
https://www.ncbi.nlm.nih.gov/pubmed/27775030
http://dx.doi.org/10.1038/srep35006

Ejemplares similares