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αβ T cell receptor germline CDR regions moderate contact with MHC ligands and regulate peptide cross-reactivity

αβ T cells respond to peptide epitopes presented by major histocompatibility complex (MHC) molecules. The role of T cell receptor (TCR) germline complementarity determining regions (CDR1 and 2) in MHC restriction is not well understood. Here, we examine T cell development, MHC restriction and antige...

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Detalles Bibliográficos
Autores principales:	Attaf, Meriem, Holland, Stephan J., Bartok, Istvan, Dyson, Julian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075794/ https://www.ncbi.nlm.nih.gov/pubmed/27775030 http://dx.doi.org/10.1038/srep35006

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