Cell resistance to the Cytolethal Distending Toxin involves an association of DNA repair mechanisms

The Cytolethal Distending Toxin (CDT), produced by many bacteria, has been associated with various diseases including cancer. CDT induces DNA double-strand breaks (DSBs), leading to cell death or mutagenesis if misrepaired. At low doses of CDT, other DNA lesions precede replication-dependent DSB for...

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Detalles Bibliográficos
Autores principales: Bezine, Elisabeth, Malaisé, Yann, Loeuillet, Aurore, Chevalier, Marianne, Boutet-Robinet, Elisa, Salles, Bernard, Mirey, Gladys, Vignard, Julien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075911/
https://www.ncbi.nlm.nih.gov/pubmed/27775089
http://dx.doi.org/10.1038/srep36022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075911/
https://www.ncbi.nlm.nih.gov/pubmed/27775089
http://dx.doi.org/10.1038/srep36022

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