Ligand-induced Epitope Masking: DISSOCIATION OF INTEGRIN α5β1-FIBRONECTIN COMPLEXES ONLY BY MONOCLONAL ANTIBODIES WITH AN ALLOSTERIC MODE OF ACTION

We previously demonstrated that Arg-Gly-Asp (RGD)-containing ligand-mimetic inhibitors of integrins are unable to dissociate pre-formed integrin-fibronectin complexes (IFCs). These observations suggested that amino acid residues involved in integrin-fibronectin binding become obscured in the ligand-...

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Detalles Bibliográficos
Autores principales: Mould, A. Paul, Askari, Janet A., Byron, Adam, Takada, Yoshikazu, Jowitt, Thomas A., Humphries, Martin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2016
Materias:
Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5076510/
https://www.ncbi.nlm.nih.gov/pubmed/27484800
http://dx.doi.org/10.1074/jbc.M116.736942

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5076510/
https://www.ncbi.nlm.nih.gov/pubmed/27484800
http://dx.doi.org/10.1074/jbc.M116.736942

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