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Ligand-induced Epitope Masking: DISSOCIATION OF INTEGRIN α5β1-FIBRONECTIN COMPLEXES ONLY BY MONOCLONAL ANTIBODIES WITH AN ALLOSTERIC MODE OF ACTION

We previously demonstrated that Arg-Gly-Asp (RGD)-containing ligand-mimetic inhibitors of integrins are unable to dissociate pre-formed integrin-fibronectin complexes (IFCs). These observations suggested that amino acid residues involved in integrin-fibronectin binding become obscured in the ligand-...

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Detalles Bibliográficos
Autores principales:	Mould, A. Paul, Askari, Janet A., Byron, Adam, Takada, Yoshikazu, Jowitt, Thomas A., Humphries, Martin J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2016
Materias:	Molecular Biophysics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5076510/ https://www.ncbi.nlm.nih.gov/pubmed/27484800 http://dx.doi.org/10.1074/jbc.M116.736942

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