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The Impact of N-terminal Acetylation of α-Synuclein on Phospholipid Membrane Binding and Fibril Structure

Human α-synuclein (αS) has been shown to be N terminally acetylated in its physiological state. This modification is proposed to modulate the function and aggregation of αS into amyloid fibrils. Using bacterially expressed acetylated-αS (NTAc-αS) and endogenous αS (Endo-αS) from human erythrocytes,...

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Detalles Bibliográficos
Autores principales: Iyer, Aditya, Roeters, Steven J., Schilderink, Nathalie, Hommersom, Bob, Heeren, Ron M. A., Woutersen, Sander, Claessens, Mireille M. A. E., Subramaniam, Vinod
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5076520/
https://www.ncbi.nlm.nih.gov/pubmed/27531743
http://dx.doi.org/10.1074/jbc.M116.726612