Binding Sites for Acylated Trehalose Analogs of Glycolipid Ligands on an Extended Carbohydrate Recognition Domain of the Macrophage Receptor Mincle

The macrophage receptor mincle binds to trehalose dimycolate on the surface of Mycobacterium tuberculosis. Signaling initiated by this interaction leads to cytokine production, which underlies the ability of mycobacteria to evade the immune system and also to function as adjuvants. In previous work...

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Detalles Bibliográficos
Autores principales: Feinberg, Hadar, Rambaruth, Neela D. S., Jégouzo, Sabine A. F., Jacobsen, Kristian M., Djurhuus, Rasmus, Poulsen, Thomas B., Weis, William I., Taylor, Maureen E., Drickamer, Kurt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2016
Materias:
Glycobiology and Extracellular Matrices
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5076529/
https://www.ncbi.nlm.nih.gov/pubmed/27542410
http://dx.doi.org/10.1074/jbc.M116.749515

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5076529/
https://www.ncbi.nlm.nih.gov/pubmed/27542410
http://dx.doi.org/10.1074/jbc.M116.749515

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