Lys-63-linked Ubiquitination of γ-Aminobutyric Acid (GABA), Type B1, at Multiple Sites by the E3 Ligase Mind Bomb-2 Targets GABA(B) Receptors to Lysosomal Degradation

GABA(B) receptors are heterodimeric G protein-coupled receptors, which control neuronal excitability by mediating prolonged inhibition. The magnitude of GABA(B) receptor-mediated inhibition essentially depends on the amount of receptors in the plasma membrane. However, the factors regulating cell su...

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Detalles Bibliográficos
Autores principales: Zemoura, Khaled, Trümpler, Claudia, Benke, Dietmar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2016
Materias:
Neurobiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5076837/
https://www.ncbi.nlm.nih.gov/pubmed/27573246
http://dx.doi.org/10.1074/jbc.M116.750968

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5076837/
https://www.ncbi.nlm.nih.gov/pubmed/27573246
http://dx.doi.org/10.1074/jbc.M116.750968

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