Distinct C9orf72-Associated Dipeptide Repeat Structures Correlate with Neuronal Toxicity

Hexanucleotide repeat expansions in C9orf72 are the most common inherited cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The expansions elicit toxicity in part through repeat-associated non-AUG (RAN) translation of the intronic (GGGGCC)(n) sequence into dipeptide rep...

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Detalles Bibliográficos
Autores principales: Flores, Brittany N., Dulchavsky, Mark E., Krans, Amy, Sawaya, Michael R., Paulson, Henry L., Todd, Peter K., Barmada, Sami J., Ivanova, Magdalena I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5077081/
https://www.ncbi.nlm.nih.gov/pubmed/27776165
http://dx.doi.org/10.1371/journal.pone.0165084

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5077081/
https://www.ncbi.nlm.nih.gov/pubmed/27776165
http://dx.doi.org/10.1371/journal.pone.0165084

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