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Glucosamine Downregulates the IL-1β-Induced Expression of Proinflammatory Cytokine Genes in Human Synovial MH7A Cells by O-GlcNAc Modification-Dependent and -Independent Mechanisms

Osteoarthritis (OA) is one of the major joint diseases, and the synovial inflammation is involved in the pathogenesis and progression of OA. Glucosamine (GlcN) is widely used as a dietary supplement for OA, and is expected to exert the antiinflammatory action in OA. However, the detailed mechanism f...

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Detalles Bibliográficos
Autores principales: Someya, Akimasa, Ikegami, Takako, Sakamoto, Koji, Nagaoka, Isao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5077170/
https://www.ncbi.nlm.nih.gov/pubmed/27776166
http://dx.doi.org/10.1371/journal.pone.0165158