Cooperation of Nutlin-3a and a Wip1 inhibitor to induce p53 activity

Targeting the Mdm2 oncoprotein by drugs has the potential of re-establishing p53 function and tumor suppression. However, Mdm2-antagonizing drug candidates, e. g. Nutlin-3a, often fail to abolish cancer cell growth sustainably. To overcome these limitations, we inhibited Mdm2 and simultaneously a se...

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Detalles Bibliográficos
Autores principales: Sriraman, Anusha, Radovanovic, Marija, Wienken, Magdalena, Najafova, Zeynab, Li, Yizhu, Dobbelstein, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5077964/
https://www.ncbi.nlm.nih.gov/pubmed/27183917
http://dx.doi.org/10.18632/oncotarget.9302

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5077964/
https://www.ncbi.nlm.nih.gov/pubmed/27183917
http://dx.doi.org/10.18632/oncotarget.9302

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