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STAT3 and NF-κB cooperatively control in vitro spontaneous apoptosis and poor chemo-responsiveness in patients with chronic lymphocytic leukemia

Chronic lymphocytic leukemia (CLL) is an adult disease characterized by in vivo accumulation of mature CD5/CD19/CD23 triple positive B cells and is currently incurable. CLL cells undergo spontaneous apoptosis in response to in vitro cell culture condition but the underlying mechanism is unclear. We...

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Detalles Bibliográficos
Autores principales: Liu, Feng-Ting, Jia, Li, Wang, Ping, Wang, Huaqing, Farren, Timothy W., Agrawal, Samir G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5077994/
https://www.ncbi.nlm.nih.gov/pubmed/27074565
http://dx.doi.org/10.18632/oncotarget.8672