Repurposed drug screen identifies cardiac glycosides as inhibitors of TGF-β-induced cancer-associated fibroblast differentiation

The tumor microenvironment, primarily composed of myofibroblasts, directly influences the progression of solid tumors. Through secretion of growth factors, extracellular matrix deposition, and contractile mechanotransduction, myofibroblasts, or cancer-associated fibroblasts (CAFs), support angiogene...

Descripción completa

Detalles Bibliográficos
Autores principales: Coleman, David T., Gray, Alana L., Stephens, Charles A., Scott, Matthew L., Cardelli, James A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078007/
https://www.ncbi.nlm.nih.gov/pubmed/27058757
http://dx.doi.org/10.18632/oncotarget.8609

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078007/
https://www.ncbi.nlm.nih.gov/pubmed/27058757
http://dx.doi.org/10.18632/oncotarget.8609

Ejemplares similares