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Repurposed drug screen identifies cardiac glycosides as inhibitors of TGF-β-induced cancer-associated fibroblast differentiation
The tumor microenvironment, primarily composed of myofibroblasts, directly influences the progression of solid tumors. Through secretion of growth factors, extracellular matrix deposition, and contractile mechanotransduction, myofibroblasts, or cancer-associated fibroblasts (CAFs), support angiogene...
Autores principales: | Coleman, David T., Gray, Alana L., Stephens, Charles A., Scott, Matthew L., Cardelli, James A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078007/ https://www.ncbi.nlm.nih.gov/pubmed/27058757 http://dx.doi.org/10.18632/oncotarget.8609 |
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