Inulanolide A as a new dual inhibitor of NFAT1-MDM2 pathway for breast cancer therapy

The transcription factor NFAT1 and the oncogene MDM2 have crucial roles in breast cancer development, progression, and metastasis. We have recently discovered that NFAT1 activates MDM2 expression. Here, we identified a small molecule (named Inulanolide A) that dually inhibited both NFAT1 and MDM2 in...

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Detalles Bibliográficos
Autores principales: Qin, Jiang-Jiang, Wang, Wei, Sarkar, Sushanta, Voruganti, Sukesh, Agarwal, Rajesh, Zhang, Ruiwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078034/
https://www.ncbi.nlm.nih.gov/pubmed/27105525
http://dx.doi.org/10.18632/oncotarget.8873

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078034/
https://www.ncbi.nlm.nih.gov/pubmed/27105525
http://dx.doi.org/10.18632/oncotarget.8873

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