Downregulation of cyclin D1 sensitizes cancer cells to MDM2 antagonist Nutlin-3

The MDM2-p53 pathway has a prominent oncogenic function in the pathogenesis of various cancers. Nutlin-3, a small-molecule antagonist of MDM2-p53 interaction, inhibits proliferation in cancer cells with wild-type p53. Herein, we evaluate the expression of MDM2, both the full length and a splicing va...

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Detalles Bibliográficos
Autores principales: Yang, Peipei, Chen, Weicai, Li, Xuhui, Eilers, Grant, He, Quan, Liu, Lili, Wu, Yeqing, Wu, Yuehong, Yu, Wei, Fletcher, Jonathan A., Ou, Wen-Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078041/
https://www.ncbi.nlm.nih.gov/pubmed/27129163
http://dx.doi.org/10.18632/oncotarget.8999

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078041/
https://www.ncbi.nlm.nih.gov/pubmed/27129163
http://dx.doi.org/10.18632/oncotarget.8999

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