Cargando…

A novel TP53 variant (rs78378222 A > C) in the polyadenylation signal is associated with increased cancer susceptibility: evidence from a meta-analysis

Polymorphisms in TP53 are involved in the progression of different types of cancer. A rare novel TP53 variant (rs78378222 A > C allele) was found via whole-genome sequencing in 2011. This variant was shown to significantly increase the risk of glioma, colorectal adenoma and prostate cancer. Funct...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Ying, Wu, Xue-Song, He, Jing, Ma, Tianjiao, Lei, Wei, Shen, Zhen-Ya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078057/ https://www.ncbi.nlm.nih.gov/pubmed/27147571 http://dx.doi.org/10.18632/oncotarget.9056

Ejemplares similares

Low penetrance susceptibility to glioma is caused by the TP53 variant rs78378222
por: Enciso-Mora, V, et al.
Publicado: (2013)

Association between a rare novel TP53 variant (rs78378222) and melanoma, squamous cell carcinoma of head and neck and lung cancer susceptibility in non-Hispanic Whites
por: Guan, Xiaoxiang, et al.
Publicado: (2013)

The rs78378222 prevalence and the copy loss of the protective allele A in the tumor tissue of diffuse large B-cell lymphoma
por: Voropaeva, Elena N., et al.
Publicado: (2020)

MON-519 In Silico Analysis of rs1042522 and rs1042522 Polymorphic Variants of TP53 Gene
por: Bó, Izabela Dal, et al.
Publicado: (2020)

Effect of TP53 rs1042522 on the susceptibility of patients to oral squamous cell carcinoma and oral leukoplakia: a meta-analysis
por: Sun, Zhen, et al.
Publicado: (2018)

The Functional TP53 rs1042522 and MDM4 rs4245739 Genetic Variants Contribute to Non-Hodgkin Lymphoma Risk
por: Fan, Chuanbo, et al.
Publicado: (2014)

Association Analysis of TP53 rs1042522, MDM2 rs2279744, rs3730485, MDM4 rs4245739 Variants and Acute Myeloid Leukemia Susceptibility, Risk Stratification Scores, and Clinical Features: An Exploratory Study
por: Tripon, Florin, et al.
Publicado: (2020)

Tissue-specific microRNA expression alters cancer susceptibility conferred by a TP53 noncoding variant
por: Deng, Qipan, et al.
Publicado: (2019)

TP53 rs1042522 polymorphism and early-onset breast cancer
por: Icen-Taskin, Irmak, et al.
Publicado: (2020)

Association of miR-34b/c rs4938723 and TP53 Arg72Pro Polymorphisms with Neuroblastoma Susceptibility: Evidence from Seven Centers()
por: Li, Le, et al.
Publicado: (2019)

Comprehensive Identification of Deleterious TP53 Missense VUS Variants Based on Their Impact on TP53 Structural Stability
por: Tam, Benjamin, et al.
Publicado: (2021)

TP53 (rs1042522, rs28934571) and TP21 (rs1801270, rs1059234) Polymorphisms and Risk of Breast Cancer among Rural Women of Maharashtra: Findings from a Hospital Based Case- Control Study
por: Datkhile, Kailas D, et al.
Publicado: (2023)

Association of TP53 rs1042522 G > C, MDM2 rs2279744 T > G, and miR-34b/c rs4938723 T > C polymorphisms with aneuploidy pregnancy susceptibility
por: Chan, Ying, et al.
Publicado: (2023)

TP53 rs1042522 C>G polymorphism and Wilms tumor susceptibility in Chinese children: a four-center case–control study
por: Liu, Peng, et al.
Publicado: (2019)

TP53 structural variants in metastatic prostatic carcinoma
por: Sirohi, Deepika, et al.
Publicado: (2019)

Mitigating the Risk of t-MNs Development: TP53 or Not TP53?
por: Tesio, Melania
Publicado: (2023)

The TP53 website: an integrative resource centre for the TP53 mutation database and TP53 mutant analysis
por: Leroy, Bernard, et al.
Publicado: (2013)

TP53 inhibitor PFTα increases the sensitivity of arsenic trioxide in TP53 wildtype tumor cells
por: Wang, Haiwei, et al.
Publicado: (2022)

TP53 variants in p53 signatures and the clonality of STICs in RRSO samples
por: Akahane, Tomoko, et al.
Publicado: (2022)

Variants in TPO rs2048722, PTCSC2 rs925489 and SEMA4G rs4919510 affect thyroid carcinoma susceptibility risk
por: Shen, Zhen, et al.
Publicado: (2023)

Intronic TP53 Polymorphisms Are Associated with Increased Δ133TP53 Transcript, Immune Infiltration and Cancer Risk
por: Eiholzer, Ramona A., et al.
Publicado: (2020)

Molecular characterization of AML‐MRC reveals TP53 mutation as an adverse prognostic factor irrespective of MRC‐defining criteria, TP53 allelic state, or TP53 variant allele frequency
por: Zhao, Davidson, et al.
Publicado: (2022)

Whole-body MRI within a surveillance program for carriers with clinically actionable germline TP53 variants - the Swedish constitutional TP53 study SWEP53
por: Omran, Meis, et al.
Publicado: (2020)

Common genetic variants in the TP53 pathway and their impact on cancer
por: Barnoud, Thibaut, et al.
Publicado: (2019)

Emerging insights into ethnic-specific TP53 germline variants
por: Fischer, Nicholas W, et al.
Publicado: (2023)

Meta-Analysis Results on the Association Between TP53 Codon 72 Polymorphism With the Susceptibility to Oral Cancer
por: Lin, Ying-Mei, et al.
Publicado: (2018)

The TP53 gene rs1042522 C>G polymorphism and neuroblastoma risk in Chinese children
por: He, Jing, et al.
Publicado: (2017)

Association of the TP53 rs1042522 C>G polymorphism and hepatoblastoma risk in Chinese children
por: Yang, Tianyou, et al.
Publicado: (2019)

Association of TP53 rs1042522 C>G Polymorphism with Glioma Risk in Chinese Children
por: Liao, Fan, et al.
Publicado: (2022)

Interaction between TP53 and XRCC1 increases susceptibility to cervical cancer development: a case control study
por: Liu, Gui-Cen, et al.
Publicado: (2019)

Common variants in the ATM, BRCA1, BRCA2, CHEK2 and TP53 cancer susceptibility genes are unlikely to increase breast cancer risk
por: Baynes, Caroline, et al.
Publicado: (2007)

The cell cycle regulatory gene polymorphisms TP53 (rs1042522) and MDM2 (rs2279744) in lung cancer: a meta-analysis
por: Bulgakova, O., et al.
Publicado: (2020)

Associations of MDM2 rs2279744 and TP53 rs1042522 polymorphisms with cervical cancer risk: A meta-analysis and systematic review
por: Yu, Meijia, et al.
Publicado: (2022)

TP53 and TP53-associated genes are correlated with the prognosis of paediatric neuroblastoma
por: Wang, Haiwei, et al.
Publicado: (2022)

TP53 Gene 72 Arg/Pro (rs1042522) single nucleotide polymorphism increases the risk and the severity of chronic lymphocytic leukemia
por: Ounalli, Asma, et al.
Publicado: (2023)

A Novel Variant in the TP53 Gene Causing Li–Fraumeni Syndrome
por: Papadimitriou, Dimitrios T., et al.
Publicado: (2023)

Tumor cells containing the African-Centric S47 variant of TP53 show increased Warburg metabolism
por: Barnoud, Thibaut, et al.
Publicado: (2019)

Association between the rs1042522 polymorphism in TP53 and prostate cancer risk: An updated meta-analysis
por: Fan, Song, et al.
Publicado: (2017)

The Investigation of Associations between TP53 rs1042522, BBC3 rs2032809, CCND1 rs9344, EGFR rs2227983 Polymorphisms and Breast Cancer Phenotype and Prognosis
por: Bekampytė, Justina, et al.
Publicado: (2021)

Somatic TP53 variants frequently confound germline testing results
por: Weitzel, Jeffrey N., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_ku072nv932bgb3ei4ntfp43b13