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Red blood cell thickness is evolutionarily constrained by slow, hemoglobin-restricted diffusion in cytoplasm

During capillary transit, red blood cells (RBCs) must exchange large quantities of CO(2) and O(2) in typically less than one second, but the degree to which this is rate-limited by diffusion through cytoplasm is not known. Gas diffusivity is intuitively assumed to be fast and this would imply that t...

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Detalles Bibliográficos
Autores principales: Richardson, Sarah L., Swietach, Pawel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078773/
https://www.ncbi.nlm.nih.gov/pubmed/27777410
http://dx.doi.org/10.1038/srep36018