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Brain iron accumulation affects myelin-related molecular systems implicated in a rare neurogenetic disease family with neuropsychiatric features

The ‘neurodegeneration with brain iron accumulation' (NBIA) disease family entails movement or cognitive impairment, often with psychiatric features. To understand how iron loading affects the brain, we studied mice with disruption of two iron regulatory genes, hemochromatosis (Hfe) and transfe...

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Detalles Bibliográficos
Autores principales: Heidari, M, Johnstone, D M, Bassett, B, Graham, R M, Chua, A C G, House, M J, Collingwood, J F, Bettencourt, C, Houlden, H, Ryten, M, Olynyk, J K, Trinder, D, Milward, E A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078858/
https://www.ncbi.nlm.nih.gov/pubmed/26728570
http://dx.doi.org/10.1038/mp.2015.192