Misassembly of full-length Disrupted-in-Schizophrenia 1 protein is linked to altered dopamine homeostasis and behavioral deficits

Disrupted-in-schizophrenia 1 (DISC1) is a mental illness gene first identified in a Scottish pedigree. So far, DISC1-dependent phenotypes in animal models have been confined to expressing mutant DISC1. Here we investigated how pathology of full-length DISC1 protein could be a major mechanism in spor...

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Detalles Bibliográficos
Autores principales: Trossbach, S V, Bader, V, Hecher, L, Pum, M E, Masoud, S T, Prikulis, I, Schäble, S, de Souza Silva, M A, Su, P, Boulat, B, Chwiesko, C, Poschmann, G, Stühler, K, Lohr, K M, Stout, K A, Oskamp, A, Godsave, S F, Müller-Schiffmann, A, Bilzer, T, Steiner, H, Peters, P J, Bauer, A, Sauvage, M, Ramsey, A J, Miller, G W, Liu, F, Seeman, P, Brandon, N J, Huston, J P, Korth, C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078859/
https://www.ncbi.nlm.nih.gov/pubmed/26754951
http://dx.doi.org/10.1038/mp.2015.194

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078859/
https://www.ncbi.nlm.nih.gov/pubmed/26754951
http://dx.doi.org/10.1038/mp.2015.194

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