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S100A8/A9, a potent serum and molecular imaging biomarker for synovial inflammation and joint destruction in seronegative experimental arthritis

BACKGROUND: Seronegative joint diseases are characterized by a lack of well-defined biomarkers since autoantibodies are not elevated. Calprotectin (S100A8/A9) is a damage-associated molecular pattern (DAMP) which is released by activated phagocytes, and high levels are found in seronegative arthriti...

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Detalles Bibliográficos
Autores principales: Geven, Edwin J. W., van den Bosch, Martijn H. J., Di Ceglie, Irene, Ascone, Giuliana, Abdollahi-Roodsaz, Shahla, Sloetjes, Annet W., Hermann, Sven, Schäfers, Michael, van de Loo, Fons A. J., van der Kraan, Peter M., Koenders, Marije I., Foell, Dirk, Roth, Johannes, Vogl, Thomas, van Lent, Peter L. E. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078998/
https://www.ncbi.nlm.nih.gov/pubmed/27776554
http://dx.doi.org/10.1186/s13075-016-1121-z