Oxidized Low‐Density Lipoprotein (OxLDL)–Treated Dendritic Cells Promote Activation of T Cells in Human Atherosclerotic Plaque and Blood, Which Is Repressed by Statins: microRNA let‐7c Is Integral to the Effect

BACKGROUND: Activated T cells and dendritic cells (DCs) are colocalized in atherosclerotic plaques in association with plaque rupture. Oxidized low‐density lipoprotein (oxLDL) promotes immune activation and inflammation. We studied the effects of statins (atorvastatin and simvastatin) on human DC ma...

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Detalles Bibliográficos
Autores principales: Frostegård, Johan, Zhang, Yong, Sun, Jitong, Yan, Keqiang, Liu, Anquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5079044/
https://www.ncbi.nlm.nih.gov/pubmed/27650878
http://dx.doi.org/10.1161/JAHA.116.003976

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5079044/
https://www.ncbi.nlm.nih.gov/pubmed/27650878
http://dx.doi.org/10.1161/JAHA.116.003976

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