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Creatinine Clearance Is Associated with Toxicity from Molecularly Targeted Agents in Phase I Trials
OBJECTIVES: This study aimed to evaluate any correlations between baseline creatinine clearance and the development of grade 3/4 toxicities during treatment within oncology phase I trials of molecularly targeted agents where entry criteria mandate a serum creatinine of ≤1.5 × the upper limit of norm...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5079100/ https://www.ncbi.nlm.nih.gov/pubmed/22889980 http://dx.doi.org/10.1159/000341152 |