STAT2 Is a Pervasive Cytokine Regulator due to Its Inhibition of STAT1 in Multiple Signaling Pathways

STAT2 is the quintessential transcription factor for type 1 interferons (IFNs), where it functions as a heterodimer with STAT1. However, the human and murine STAT2-deficient phenotypes suggest important additional and currently unidentified type 1 IFN-independent activities. Here, we show that STAT2...

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Detalles Bibliográficos
Autores principales: Ho, Johnathan, Pelzel, Christin, Begitt, Andreas, Mee, Maureen, Elsheikha, Hany M., Scott, David J., Vinkemeier, Uwe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5079630/
https://www.ncbi.nlm.nih.gov/pubmed/27780205
http://dx.doi.org/10.1371/journal.pbio.2000117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5079630/
https://www.ncbi.nlm.nih.gov/pubmed/27780205
http://dx.doi.org/10.1371/journal.pbio.2000117

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