Semi-automated closed system manufacturing of lentivirus gene-modified haematopoietic stem cells for gene therapy

Haematopoietic stem cell (HSC) gene therapy has demonstrated potential to treat many diseases. However, current state of the art requires sophisticated ex vivo gene transfer in a dedicated Good Manufacturing Practices facility, limiting availability. An automated process would improve the availabili...

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Detalles Bibliográficos
Autores principales: Adair, Jennifer E., Waters, Timothy, Haworth, Kevin G., Kubek, Sara P., Trobridge, Grant D., Hocum, Jonah D., Heimfeld, Shelly, Kiem, Hans-Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080442/
https://www.ncbi.nlm.nih.gov/pubmed/27762266
http://dx.doi.org/10.1038/ncomms13173

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080442/
https://www.ncbi.nlm.nih.gov/pubmed/27762266
http://dx.doi.org/10.1038/ncomms13173

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